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However, potential limitations should be considered. The cross sectional design precludes us from establishing a temporal association between dietary habits and telomere length.

Although all analyses were adjusted for multiple covariates, unmeasured or residual confounding could still be present. Validation of self reported variables potentially associated with telomere length, such as self reported diabetes, hypertension, and obesity, has been done previously. In summary, greater adherence to the Mediterranean diet was significantly associated with longer leukocyte telomere length, a marker of biological aging.

Our results further support the health benefits of adherence to the Mediterranean diet. Finally, we acknowledge Patrice Soule and Esther Orr for their laboratory assistance, and Meir J Stampfer, Walter Willet, and JoAnn Manson for their insightful comments on Calcium AcetateTablets (Eliphos)- FDA manuscript.

MC-B analyzed the what is detox and wrote the first draft of the manuscript. MC-B international organization of psychophysiology iop IDV contributed to all aspects of the international organization of psychophysiology iop design, data collection, data analysis and interpretation, and the writing of the article.

IDV was the expert on telomere length. TTF and FBH created and validated the dietary scores and contributed to data collection, international organization of psychophysiology iop interpretation, and the writing of the article.

BJ and QS supervised the dietary analysis and data interpretation and contributed to the writing of the article. JP contributed to telomere data cleaning and collection. JP and MD supervised telomere analysis and contributed to data interpretation and the writing of the article. KMR contributed international organization of psychophysiology iop data collection, data interpretation, and the writing of the article.

All authors read and approved the final version of the manuscript. IDV is the guarantor. MC-B is also supported by a Sara Borrell postdoctoral fellowship from the Spanish Ministry of Health, Carlos III Health Institute. MD is supported by grant R25 CA94880 from the National Cancer Institute. QS is supported by an NHLBI sponsored career development award (R00HL098459). Competing interests: All authors have completed the ICMJE uniform disclosure form at www.

Respond to this articleRegister for alerts If you drug taking registered for alerts, you should use your registered email address as your username Citation toolsDownload this article to citation manager Marta Crous-Bou postdoctoral research fellowresearch fellow, Teresa T Fung associate professoradjunct associate professor, Jennifer Prescott instructor VinCRIStine Sulfate Liposome Injection (Marqibo)- FDA international organization of psychophysiology iop, Bettina Julin postdoctoral research fellowresearch fellow, Mengmeng Du postdoctoral research fellowresearch fellow, Qi Sun assistant professor et al Crous-Bou M, Fung T T, Prescott J, Julin B, Du M, Sun Q et al.

Design Population based cohort study. Dietary assessmentIn 1980 participants completed a 61 item semi-quantitative food frequency questionnaire to assess their diet in the previous year. Telomere length measurementGenomic DNA was extracted from peripheral blood leukocytes using the QIAmp 96-spin blood protocol (Qiagen, Chatsworth, CA, USA). Strengths and limitations of studyThe strengths of our study include the large and well characterized study population, detailed assessment of dietary habits as well international organization of psychophysiology iop other sociodemographic and lifestyle characteristics, and validated food frequency questionnaires and dietary scores.

ConclusionIn summary, greater adherence to the Mediterranean diet was significantly associated with longer leukocyte telomere length, a marker of biological aging. Mediterranean diet pyramid: a cultural model for healthy eating. OpenUrlTrichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. OpenUrlCrossRefPubMedWeb of ScienceFung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB.

Mediterranean diet and incidence of and mortality from international organization of psychophysiology iop heart disease and stroke in women. The Mediterranean-style dietary pattern and mortality among men and women with cardiovascular nacl na. Primary prevention of international organization of psychophysiology iop disease with a Mediterranean diet.

OpenUrlCrossRefPubMedWeb of ScienceSamieri C, Sun Q, Townsend MK, Chiuve SE, Okereke OI, Willett WC, et al. The association between dietary patterns at midlife and health in aging: an observational study.

OpenUrlCrossRefPubMedWeb of ScienceBlackburn EH. A DNA damage checkpoint response in telomere-initiated senescence. OpenUrlCrossRefPubMedWeb of ScienceAbbott A. Chromosome protection scoops Nobel. OpenUrlCrossRefPubMedWeb of ScienceVon Zglinicki T.

Oxidative stress shortens telomeres.

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